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Role of Medium-Chain Triglycerides in the Alcohol-Mediated Cytochrome P450 2E1 Induction of Mitochondria

✍ Scribed by Charles S. Lieber; Qi Cao; Leonore M. DeCarli; Maria A. Leo; Ki M. Mak; Anatoly Ponomarenko; Chaoling Ren; Xiaolei Wang


Book ID
109123857
Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
622 KB
Volume
31
Category
Article
ISSN
0145-6008

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Cytochrome P450 2E1 (CYP2E1) may be a central pathway in generating oxidative stress, reactive oxygen species, and causing hepatotoxic injury by alcohol and various hepatotoxins. This study evaluated the ability of CYP2E1 to potentiate or synergize the hepatotoxicity of Fas in vivo. C57BL/6 mice wer