✦ LIBER ✦

Role of mediatophore in connection with proteins of the active zone in synaptic transmission

✍ Scribed by Morel, N.; Isra�l, M.

Publisher: John Wiley and Sons
Year: 2000
Tongue: English
Weight: 259 KB
Volume: 49
Category: Article
ISSN: 1059-910X
DOI: 10.1002/(sici)1097-0029(20000401)49:1<47::aid-jemt6>3.0.co;2-w

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✦ Synopsis

Mediatophore is a protein purified from Torpedo electric organ synaptosomes, which translocates acetylcholine (ACh) upon calcium action after reconstitution in artificial membranes. After expression in transfected cells, it endows these cells with a calcium-dependent release mechanism displaying clear quantal properties. The role of mediatophore in synaptic transmission is discussed in relation to the ultrastructural organization of the active zone and the cytosolic high calcium microdomains that transiently appear after presynaptic membrane depolarization.

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