Role of LINGO1 polymorphisms in Parkinson's disease

✍ Scribed by Dietrich Haubenberger; Christoph Hotzy; Walter Pirker; Regina Katzenschlager; Thomas Brücke; Fritz Zimprich; Eduard Auff; Alexander Zimprich

• Publisher: John Wiley and Sons
• Year: 2009
• Tongue: English
• Weight: 369 KB
• Volume: 24
• Category: Article
• ISSN: 0885-3185
• DOI: 10.1002/mds.22768

✦ Synopsis

Abstract

A clinical overlap between Parkinson's disease (PD) and essential tremor (ET) has prompted a discussion whether these conditions share common genetic susceptibility factors. Recently, the first genome‐wide association study in ET revealed a significant association with a variant in the LINGO1 gene. LINGO1 has also been demonstrated to play a role in the survival of dopaminergic neurons in an animal model of PD, and therefore constitutes a potential candidate gene for PD. In this study, SNPs rs9652490, rs11856808, and rs7177008 of LINGO1 were genotyped in a total of 694 Austrian subjects (349 PD, 345 controls). No association could be found between genotype or allele counts and PD. Neither did a subgroup analysis in tremor‐dominant patients with PD reveal a significant association. This study on LINGO1‐variants in PD argues against a major role of LINGO1 gene variations for PD. © 2009 Movement Disorder Society