Role of Intracellular pH in Proliferation, Transformation, and Apoptosis
โ Scribed by Lamara D. Shrode; Hans Tapper; Sergio Grinstein
- Book ID
- 110419557
- Publisher
- Springer US
- Year
- 1997
- Tongue
- English
- Weight
- 683 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0145-479X
No coin nor oath required. For personal study only.
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## Abstract Secondary cultures of human diploid fibroblasts were used to study the effect of pH on cellular proliferation. In nonconfluent cultures, the growth rate at pH 7.1 was similar to that at pH 7.7 regardless of serum concentration. However, the saturation density achieved at pH 7.7 at any s
Internalization of EGF and transferrin measured as the rate of uptake of 1251labeled ligands was compared in the cell line CCL39 and a mutant derivative, PS120, lacking the Na+/H+ antiport system. N o significant alteration was detected between the two cell lines. In contrast, pretreatment of the mu