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Role of interplay between IL-4 and IFN-γ in the in regulating M1 macrophage polarization induced by Nattectin

✍ Scribed by Edson Kiyotaka Ishizuka; Marcio José Ferreira; Lidiane Zito Grund; Erica Maria Martins Coutinho; Evilin Naname Komegae; Alexandra Anjos Cassado; Karina Ramalho Bortoluci; Monica Lopes-Ferreira; Carla Lima


Book ID
118236610
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
1022 KB
Volume
14
Category
Article
ISSN
1567-5769

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IL-4 specifically induced IgE production by peripheral blood lymphocytes or by tonsil or spleen cells from healthy donors. IL-4-induced IgE synthesis was dependent on CD4+ T cells and monocytes and was blocked by IFN-y, IFN-a, and prostaglandin E-2 (PGE-2). These substances also inhibited IL4-induce