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Role of interleukin-1β, interleukin-6 and macrophage inflammatory protein-1β in prostaglandin-E2-induced hyperthermia in rats

✍ Scribed by A. Fernández-Alonso; K. Benamar; M. SancibriÁn; F.J. López-Valpuesta; F.J. Mifiano


Book ID
116019266
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
477 KB
Volume
59
Category
Article
ISSN
0024-3205

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The chemokines, macrophage inflammatory protein-1 (MIP-1) and its subunit MIP-lP, induce an intense fever in the rat when they are injected directly into the anterior hypothalamic, pre-optic area (AH/ POA), a region containing thermosensitive neurons. The purpose of this study was to compare the cen