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Role of in vitro release models in formulation development and quality control of parenteral depots

✍ Scribed by Larsen, Claus; Larsen, Susan Weng; Jensen, Henrik; Yaghmur, Anan; Østergaard, Jesper

Book ID
119957941
Publisher
Informa plc
Year
2009
Tongue
English
Weight
821 KB
Volume
6
Category
Article
ISSN
1742-5247

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✍ Roger L. Williams; Robert A. Upton; Luann Ball; Richard L. Braun; Emil T. Lin; W 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 English ⚖ 442 KB

Development of a controlled-released formulation of chlorpheniramine maleate is described, using in vitro/in vivo correlates, according to a process that has been termed "biorelevant dissolution". The process begins with simulations using several possible input rates combined with known disposition