𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Role of Id family proteins in growth control

✍ Scribed by Yoshifumi Yokota; Seiichi Mori

Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
146 KB
Volume
190
Category
Article
ISSN
0021-9541

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Id proteins (inhibitors of DNA binding/differentiation) are negative regulators of basic helix‐loop‐helix (bHLH) type transcription factors, which promote the differentiation of various cell types. In addition to their β€œclassical” ability to inhibit cell differentiation, they are able to stimulate cell cycle progression. These facts suggest that Id proteins play a role in keeping precursor cells immature and in expanding the cell population size during development. In vitro as well as in vivo analyses in the last several years have shown that Id proteins have more complex activities; they induce apoptosis or function as survival factors, depending on the cell context. Furthermore, dysregulated expression of Id proteins has been reported in several human tumors and seems to be related to the malignant character of tumors. Here, we summarize and discuss the biological activities of Id proteins from the standpoint of cell growth control. J. Cell. Physiol. 190: 21–28, 2002. Β© 2002 Wiley‐Liss, Inc.

πŸ“œ SIMILAR VOLUMES

Role of insulin-like growth factors and
Role of insulin-like growth factors and their binding proteins in growth control and carcinogenesis
✍ Adda Grimberg; Pinchas Cohen πŸ“‚ Article πŸ“… 2000 πŸ› John Wiley and Sons 🌐 English βš– 172 KB πŸ‘ 2 views

Interest in the role of the insulin-like growth factor (IGF) axis in growth control and carcinogenesis has recently been increased by the finding of elevated serum insulin-like growth factor I (IGF-I) levels in association with three of the most prevalent cancers in the United States: prostate cance

Role of Bcl-2 family of proteins in mali
Role of Bcl-2 family of proteins in malignancy
✍ Belinda C. Baliga; Sharad Kumar πŸ“‚ Article πŸ“… 2002 πŸ› John Wiley and Sons 🌐 English βš– 114 KB

B cell lymphoma gene-2 (Bcl-2) is the prototypic member of a growing family of proteins that play evolutionarily conserved, key regulatory roles in apoptosis. The Bcl-2 family members are characterized by the presence of one or more Bcl-2 homology domains and are comprised of both the prosurvival an

Roles of maf family proteins in lens dev
Roles of maf family proteins in lens development
✍ Hasan Mahmud Reza; Kunio Yasuda πŸ“‚ Article πŸ“… 2004 πŸ› John Wiley and Sons 🌐 English βš– 326 KB

## Abstract Lens provides a good model for studying developmental cues relevant to cellular and molecular interactions. Basic region/leucine zipper (bZIP) transcription factors have been found to play key roles during eye formation in various species, including human, mouse, rat, __Xenopus__, zebra

Role of CTGF/HCS24/ecogenin in skeletal
Role of CTGF/HCS24/ecogenin in skeletal growth control
✍ Masaharu Takigawa; Tohru Nakanishi; Satoshi Kubota; Takashi Nishida πŸ“‚ Article πŸ“… 2003 πŸ› John Wiley and Sons 🌐 English βš– 347 KB

## Abstract Connective tissue growth factor/hypertrophic chondrocyte‐specific gene product 24 (CTGF/Hcs24) is a multifunctional growth factor for chondrocytes, osteoblasts, and vascular endothelial cells. CTGF/Hcs24 promotes the proliferation and maturation of growth cartilage cells and articular c