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Role of hydrophobic interactions in enzyme inhibition by drugs

✍ Scribed by Eric J. Lien; Mehdi Hussain; George L. Tong

Publisher
John Wiley and Sons
Year
1970
Tongue
English
Weight
321 KB
Volume
59
Category
Article
ISSN
0022-3549

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✦ Synopsis

The role of hydrophobic interactions in inhibiting the relatively specific enzymatic reactions of five enzyme systems by series of congeneric drugs has been illustrated by the use of substituent constants and regression analysis. The inhibition of lipoxygenase by alcohols, the inhibition of D-amino acid oxidase by maleimides, and the inhibition of hydroxyindole-o-methyltransferase by N-acyltryptamines are found to be linearly dependent on the

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