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Role of HMGB1 in doxorubicin-induced myocardial apoptosis and its regulation pathway

✍ Scribed by Yongwei Yao; Xuemei Xu; Guohui Zhang; Yingyu Zhang; Wei Qian; Tao Rui

Book ID
113039261
Publisher
Springer
Year
2012
Tongue
English
Weight
810 KB
Volume
107
Category
Article
ISSN
0300-8428

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## Abstract Mutation of tumor suppressor p53 gene gains new function in regulation of DNA damage‐induced apoptotic response in tumor cells, which may lead to a poor response in cancer chemotherapy and radiotherapy. Transfection of mutant p53 (R175H) to p53‐null osteosarcoma Saos‐2 cells suppressed