Role of H-ras gene in chronic liver damage in mice. By using transgenic mice carrying a human c-H-ras proto-oncogene without mutations

Hepatic tumors induced by carbon tetrach

Hepatic tumors induced by carbon tetrachloride in transgenic mice carrying a human c-H-ras proto-oncogene without mutations

✍ Satoshi Tsunematsu; Hidetsugu Saito; Tatehiro Kagawa; Toshio Morizane; Jun-Ichi 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 French ⚖ 1007 KB

## Abstract Hepatic tumors were generated in mice by repeated administration of carbon tetrachloride (CCI~4~). Eight transgenic (Tg) mice carrying a human c‐H‐__ras__ proto‐oncogene (rasH2 line) and 9 non‐Tg mice were killed at 20 weeks. Tg mice developed more tumors than did non‐Tg littermates. Mo