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Role of glycosylation in protein transport to the cell surface

✍ Scribed by Machamer, C.E.; Guan, J.-L.; Rose, J.K.

Book ID
122018389
Publisher
Elsevier Science
Year
1985
Tongue
English
Weight
61 KB
Volume
3
Category
Article
ISSN
0168-1702

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## Abstract Mutations in the gene encoding ClC‐5 lead to X‐linked hypercalciuric nephrolithiasis (XLHN), characterized by proteinuria, hypercalciuria, and phosphaturia. In renal proximal tubule cells, ClC‐5 was identified as an important player in endocytosis, which ensures reabsorption of filtered