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Role of Glycogen Synthase Kinase-3 in Cell Fate and Epithelial-Mesenchymal Transitions

✍ Scribed by Doble, Bradley W.; Woodgett, James R.

Book ID: 120208997
Publisher: S. Karger AG
Year: 2007
Tongue: English
Weight: 463 KB
Volume: 185
Category: Article
ISSN: 1422-6405
DOI: 10.1159/000101306

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## Abstract Idiopathic pulmonary fibrosis is characterized by myofibroblast accumulation, extracellular matrix (ECM) remodeling, and excessive collagen deposition. ECM‐producing myofibroblasts may originate from epithelial cells through epithelial to mesenchymal transition (EMT). TGF‐β1 is an induc