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Role of genetic drift in the high frequency of Tay-Sachs disease among Ashkenazic Jews

✍ Scribed by SHOZO YOKOYAMA


Book ID
115248827
Publisher
John Wiley and Sons
Year
1979
Tongue
English
Weight
289 KB
Volume
43
Category
Article
ISSN
0003-4800

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Tay-Sachs disease (TSD), a neurodegenerative disorder resulting from a deficiency of the lysosomal enzyme hexosaminidase A (HexA), clusters in Ashkenazic Jews. Population-based screening programs to detect carriers of TSD genes by means of HexA assays have been active since the 1970s. The recent cha