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Role of galanin receptor 1 in the galanin-induced inhibition of intestinal motility

✍ Scribed by Sternini, Catia; Balestra, Barbara; Pham, Thomas; Spelta, Valeria; D'Agostino, Gianluigi; Reeve, Joseph R.; Won, Helen; Walsh, John H.; Tonini, Marcello

Book ID: 122556323
Publisher: Elsevier Science
Year: 2000
Tongue: English
Weight: 200 KB
Volume: 118
Category: Article
ISSN: 0016-5085
DOI: 10.1016/S0016-5085(00)83733-6

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## Abstract Galanin activates three receptors, the galanin receptor 1 (GalR1), GalR2, and GalR3. In the gastrointestinal tract, GalR1 mediates the galanin inhibition of cholinergic transmission to the longitudinal muscle and reduction of peristalsis efficiency in the small intestine. Galanin has al