Altered G1 phase regulation in osteosarc
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M. Serena Benassi; Lara Molendini; Gabriella Gamberi; M. Rosa Sollazzo; Paola Ra
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Article
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1997
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John Wiley and Sons
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French
β 508 KB
Alterations in the normal cell cycle lead to abnormal cell proliferation and to tumor development. To explore the role of the cyclin D/Cdk4 complex and the retinoblastoma protein (pRb) in the growth and spread of osteoblastic osteosarcoma (OS), 40 tumor samples were selected. In 17 of these cases, l