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Role of Flexibility and Polarity as Determinants of the Hydration of Internal Cavities and Pockets in Proteins

✍ Scribed by Damjanović, Ana; Schlessman, Jamie L.; Fitch, Carolyn A.; García, Angel E.; García-Moreno E., Bertrand

Book ID
119921071
Publisher
Biophysical Society
Year
2007
Tongue
English
Weight
795 KB
Volume
93
Category
Article
ISSN
0006-3495

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## Abstract The solvent accessible surface area (SASA) algorithm is conventionally used to characterize protein surfaces in electrostatic energy computations of proteins. Unfortunately, it often fails to find narrow cavities inside a protein. As a consequence p__K__~a~ computations based on this al