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Role of fibroblasts and fibroblast-derived growth factors in periprosthetic angiogenesis

✍ Scribed by Miklos Tunyogi-Csapo; Tamas Koreny; Csaba Vermes; Jorge O. Galante; Joshua J. Jacobs; Tibor T. Glant

Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
350 KB
Volume
25
Category
Article
ISSN
0736-0266

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The periprosthetic granulomatous soft tissue [designated iterfacial membrane (IFM) in this study] exhibits heterogeneous histopathological features, in which highly vascularized areas with dense cellularity alternate with fibrotic and pseudocapsule‐like tissue structures. Although macrophage/monocyte activation is a prominent event in the periprosthetic environment, fibroblasts also phagocytose particulate wear debris both in vivo and in vitro. Particulate wear debris and/or cytokines/growth factors alone or in combination (e.g., in conditioned media of explant cultures of IFMs) stimulated normal synovial and IFM fibroblasts to express inflammatory mediators and growth factors such as interleukin (IL)‐1β, IL‐6, IL‐8, three isoforms of vascular endothelial growth factor (VEGF), monocyte/macrophage chemoattractant protein‐1 (MCP‐1), macrophage‐colony‐stimulating factor (M‐CSF), cycloxygenases (Cox‐1 and Cox‐2), acid‐ and basic‐fibroblast growth factors (FGF‐1 and FGF‐2), leukemia inhibitory factor‐1 (LIF‐1), transforming growth factor β‐1 (TGF‐β1), receptor activator of nuclear factor‐kappa B ligand (RANKL), and osteoprotegerin (OPG). Thus, the fibroblast is capable of expressing a wide array of angiogenic and osteoclastogenic factors which are involved in the detrimental processes of the periprosthetic osteolysis. © 2007 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 25:1378–1388, 2007

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