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Role of extracellular matrix in insulin-like growth factor (IGF) binding protein-2 regulation of IGF-II action in normal human osteoblasts

✍ Scribed by Cheryl A. Conover; Sundeep Khosla

Book ID
117987794
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
227 KB
Volume
13
Category
Article
ISSN
1096-6374

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## Abstract While extracellular acidification within solid tumors is well‐documented, how reduced pH impacts regulation of insulin‐like growth factor‐I (IGF‐I) has not been studied extensively. Because IGF‐I receptor binding is affected by IGF binding proteins (IGFBPs), we examined how pH impacted