Role of estrogens in phenobarbital induction of liver microsomal enzymes
โ Scribed by P. V. Sergeev; N. N. Vedernikova; A. I. Maiskii; N. V. Shapoval; V. A. Volov
- Publisher
- Springer US
- Year
- 1975
- Tongue
- English
- Weight
- 242 KB
- Volume
- 80
- Category
- Article
- ISSN
- 0007-4888
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The eects of age on hepatic microsomal enzyme induction were studied in male CD-1 mice. Six week old and 1 year old animals were treated with either phenobarbital (80 mg kg 71 ) or saline once daily for 3 d. Twenty-four hours after the last treatment, animals were sacriยฎced and livers were harvested
Postmortem changes in the drug-metabolizing enzymes in rat liver microsome were studied. Parameters investigated were: microsomal protein, NADPH-cytochrome P-450 reductase activity, NADH-cytochrome b5 reductase activity, cytochrome b5 content, cytochrome P-450 content, aminopyrine N-demethylase acti