Role of erbB2 in breast cancer chemosensitivity
β Scribed by Dihua Yu; Mien-Chie Hung
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 117 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0265-9247
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
The cell-surface receptor tyrosine kinase protein c-erbB-2 is immunocytochemically detected as membrane staining on the surface of cancer cells in 20-30% of cases of breast cancer, and its presence has been associated with poor prognosis for the patient. However, there have been numerous reports of
Overexpression of gp185 erbB-2 has been associated with reduced survival in breast-cancer patients. Our earlier results, now confirmed in a larger cohort of patients ( ), evidenced that the HLA-A2 allele may participate in the modulation of the erbB-2 tumor phenotype in vivo. In the present study, w