𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Role of environmental factors in axial skeletal dysmorphogenesis

✍ Scribed by Peter G. Alexander; Rocky S. Tuan

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
505 KB
Volume
90
Category
Article
ISSN
1542-975X

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Approximately 1 in 1000 live births is afflicted with an axial skeletal defect. Although many of the known human teratogens can produce axial skeletal defects, the etiology of over half of the observed defects is unknown. The high morbidity associated with these defects demands that we continue to elucidate the mechanisms of axial skeletal teratogens. Advances in cell and molecular biology with respect to normal development and somitogenesis and the pathogenesis and mechanisms of teratogenesis are occurring at a tremendous rate. This allows teratologists and developmental toxicologists the opportunity to revisit old problems with new tools to elucidate common mechanisms between various environmental insults and discover novel targets that aid in the understanding of normal and pathogenic development of the spine. Birth Defects Research (Part C) 90:118–132, 2010. Β© 2010 Wiley‐Liss, Inc.

πŸ“œ SIMILAR VOLUMES

The role of environmental factors in gro
The role of environmental factors in growth accounting
✍ Byung M. Jeon; Robin C. Sickles πŸ“‚ Article πŸ“… 2004 πŸ› John Wiley and Sons 🌐 English βš– 216 KB πŸ‘ 1 views

## Abstract This paper explores a relatively new methodology, the directional distance function method, to analyse productivity growth. The method allows us to explicitly evaluate the role that undesirable outputs of the economy, such as carbon dioxide and other greenhouse gases, have on the fronti

Role of nitric oxide in chick embryonic
Role of nitric oxide in chick embryonic organogenesis and dysmorphogenesis
✍ Peter G. Alexander; Lillian Chau; Rocky S. Tuan πŸ“‚ Article πŸ“… 2007 πŸ› John Wiley and Sons 🌐 English βš– 417 KB πŸ‘ 1 views

## Abstract **BACKGROUND:** Nitric oxide (NO), produced by the nitric oxide synthase family of enzymes, mediates multiple signaling functions, and when unchecked, NO causes pathological damage. Exposure of embryos to a variety of teratogens, including carbon monoxide (CO), has been shown to increas

The role of leukemia inhibitory factor i
The role of leukemia inhibitory factor in skeletal muscle regeneration
✍ John B. Kurek; John J. Bower; Margarita Romanella; Frank Koentgen; Mark Murphy; πŸ“‚ Article πŸ“… 1997 πŸ› John Wiley and Sons 🌐 English βš– 390 KB πŸ‘ 2 views

Although a number of cytokines have been implicated in tissue regeneration, it is unknown which ones actually function in vivo. Here, we use mice with a targeted mutation in the leukemia inhibitory factor (LIF) gene to examine the role of LIF in muscle regeneration. Using a muscle crush model, we sh