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Role of endothelin cascade between keratinocytes and melanocytes in hyperpigmentation in senile freckle

✍ Scribed by Tajima, Satsuki; Manaka, Izumi; Kawashima, Makoto; Kobayashi, Takeshi; Imokawa, Genji


Book ID
119562371
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
162 KB
Volume
16
Category
Article
ISSN
0923-1811

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## Abstract The development of melanocytes from neural crest‐derived precursor cells depends on signaling by the receptor tyrosine kinase KIT and the G protein‐coupled endothelin receptor B (EDNRB) pathways. Loss‐of‐function mutations in either of these two signaling receptor molecules cause a loss