Role of endothelin-1, sodium hydrogen exchanger-1 and mitogen activated protein kinase (MAPK) activation in glucose-induced cardiomyocyte hypertrophy

Apoptotic insults to human chondrocytes

Apoptotic insults to human chondrocytes induced by sodium nitroprusside are involved in sequential events, including cytoskeletal remodeling, phosphorylation of mitogen-activated protein kinase kinase kinase-1/c-Jun N-terminal kinase, and Bax-Mitochondria-Mediated caspase activation

✍ Yih-Giun Cherng; Hua-Chia Chang; Yi-Ling Lin; Ming-Liang Kuo; Wen-Ta Chiu; Ruei- 📂 Article 📅 2008 🏛 Elsevier Science 🌐 English ⚖ 679 KB

## Abstract Nitric oxide (NO) can regulate chondrocyte activities. This study was aimed to evaluate the molecular mechanisms of NO donor sodium nitroprusside (SNP)‐induced insults to human chondrocytes. Exposure of human chondrocytes to SNP increased cellular NO levels but decreased cell viability