Role of Endonucleases XPF and XPG in Nucleotide Excision Repair of Platinated DNA and Cisplatin/Oxaliplatin Cytotoxicity

Spontaneous mutation, oxidative DNA dama

Spontaneous mutation, oxidative DNA damage, and the roles of base and nucleotide excision repair in the yeast Saccharomyces cerevisiae

✍ Andrew D. Scott; Maryam Neishabury; D. Hugh Jones; Simon H. Reed; Serge Boiteux; 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 315 KB 👁 2 views

The OGG1 gene of Saccharomyces cerevisiae encodes a DNA glycosylase that excises 7,8-dihydro-8-oxoguanine (8-OxoG). When compared to wild-type, ogg1 mutants show an increase in the frequency of GC to TA transversions, indicating a role for Ogg1 in the repair of 8-OxoG. Here we report an increased fr