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Role of endonuclease G in neuronal excitotoxicity in mice

โœ Scribed by Yongfei Wu; Mei Dong; Nicholas J Toepfer; Yunxia Fan; Ming Xu; Jianhua Zhang

Book ID
116766783
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
308 KB
Volume
364
Category
Article
ISSN
0304-3940

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## Abstract The pathologic activation of NMDA receptors by glutamate is a major contributor to neuronal cell death after stroke. Receptor activation causes a massive influx of calcium into the neuron that is accumulated by the mitochondria. The favored hypothesis is that the calcium loaded mitochon