Role of endogenous interferon in the anti-tumor effect of poly I·C and statolon as demonstrated by the use of anti-mouse interferon serum

✍ Scribed by Ion Gresser; Chantal Maury; Marie-Thérèse Bandu; Michael Tovey; Marie-Thérèse Maunoury

• Publisher: John Wiley and Sons
• Year: 1978
• Tongue: French
• Weight: 559 KB
• Volume: 21
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/ijc.2910210113

✦ Synopsis

Abstract

We have determined the effect of sheep anti‐mouse interferon globulin on the anti‐tumor effects of poly I·C, statolon, tilorone, pyran copolymer and BCG in mice inoculated with Ehrlich ascites or L 1210 lymphoma cells. Whereas the anti‐tumor effects of poly I·C and statolon were nullified when mice were injected with immunoglobulins, the anti‐tumor effects of pyran copolymer and BCG were not modified by this treatment. We conclude that interferon mediates the anti‐tumor activity of poly I·C and statolon in these experimental systems. It is suggested that anti‐interferon serum provides a direct method of determining whether other biologic effects attributed to viruses, poly I·C, statolon, tilorone, pyran copolymer (and possibly other interferon inducers) are mediated or not by interferon.