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Role of endogenous glutathione in the metabolism of glyceryl trinitrate by isolated perfused rat liver

✍ Scribed by Philip Needleman; Anne B. Harkey

Book ID
115770973
Publisher
Elsevier Science
Year
1971
Tongue
English
Weight
816 KB
Volume
20
Category
Article
ISSN
0006-2952

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Role of liver glutathione in 1,1-dichlor
Role of liver glutathione in 1,1-dichloroethylene metabolism and hepatotoxicity in intact rats and isolated perfused rat liver
✍ D. Reichert; H. W. Werner; D. Henschler πŸ“‚ Article πŸ“… 1978 πŸ› Springer-Verlag 🌐 English βš– 507 KB

The liver glutathione content was measured after oral administration of 1,1-dichloroethylene (vinylidene chloride = VDC; dissolved in olive oil) and its significance for the metabolism and hepatotoxicity of VDC was investigated. After treatment with 1000 mg/kg VDC p.o., glutathione decreased to 33%