Role of Eicosanoids in Prostate Cancer Progression
β Scribed by Daotai Nie; Mingxin Che; David Grignon; Keqin Tang; Kenneth V. Honn
- Book ID
- 110338274
- Publisher
- Springer
- Year
- 2001
- Tongue
- English
- Weight
- 565 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0167-7659
No coin nor oath required. For personal study only.
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## Abstract The metalloproteinase ADAM15 is a multiβdomain disintegrin protease that is upregulated in a variety of human cancers. ADAM15 mRNA and protein levels are increased in prostate cancer and its expression is significantly increased during metastatic progression. It is likely that ADAM15 su
## Abstract When prostate cancer is first detected it generally is dependent on the presence of androgens for growth, and responds to androgen ablation therapies. However, the disease often recurs in a disseminated and apparently androgen independent (AI) form, and in this state is almost invariabl