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Role of Disrupted-in-Schizophrenia-1 (DISC1) in amyloid precursor protein (APP) processing and Aβ generation

✍ Scribed by Shahani, Neelam; Young-Pearse, Tracy; Selkoe, Dennis; Sawa, Akira

Book ID
123106556
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
58 KB
Volume
6
Category
Article
ISSN
1552-5260

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## Abstract The amyloid precursor protein (APP) is cleaved enzymatically by nonamyloidogenic and amyloidogenic pathways. α‐Secretase (α‐secretase), cleaves APP within the β‐amyloid (Aβ) sequence, resulting in the release of a secreted fragment of APP (αAPPs) and precluding Aβ generation. In this st