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Role of dipeptidyl peptidase IV (DPP4) in the development of dyslipidemia: DPP4 contributes to the steroid metabolism pathway

โœ Scribed by Youichi Sato; Sakura Koshioka; Yasushi Kirino; Takayuki Kamimoto; Kazuyoshi Kawazoe; Shinji Abe; Kazuo Minakuchi; Yutaka Nakahori


Book ID
116719892
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
579 KB
Volume
88
Category
Article
ISSN
0024-3205

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## Abstract Linagliptin (BI 1356) is a novel dipeptidyl peptidaseโ€4 (DPPโ€4) inhibitor in clinical development for the treatment of type 2 diabetes. It exhibits nonโ€linear pharmacokinetics and shows concentrationโ€dependent plasma protein binding to its target, DPPโ€4. The aim of this study was to inv