✦ LIBER ✦

Role of dendritic and follicular dendritic cells in HIV infection and pathogenesis

✍ Scribed by Geraldine Grouard; Edward A Clark

Publisher: Elsevier Science
Year: 1997
Tongue: English
Weight: 423 KB
Volume: 9
Category: Article
ISSN: 0952-7915
DOI: 10.1016/s0952-7915(97)80111-2

No coin nor oath required. For personal study only.

✦ Synopsis

Dendritic cells (DCs) and follicular dendritic cells (FDCs) play important roles in HIV-mediated pathogenesis. Recent studies have defined new DC subsets and shown that DCs in lymphoid mucosa can both harbor virus and stimulate its spread into CD4 + T cells. FDCs harbor unspliced HIV mRNA and immune complexed virus, but not actively infectious virus, yet these cells are a key regulated reservoir of virions.

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