✦ LIBER ✦

Role of cytokines in bone resorption

✍ Scribed by Gregory R. Mundy

Publisher: John Wiley and Sons
Year: 1993
Tongue: English
Weight: 501 KB
Volume: 53
Category: Article
ISSN: 0730-2312
DOI: 10.1002/jcb.240530405

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Osteoclastic bone resorption is modulated in humans by powerful osteotropic factors which are generated in the immediate vicinity of bone resorbing surfaces. These factors are released from marrow mononuclear cells and from some bone cells, and some are actually incorporated into the noncollagenous bone matrix from where they are released when bone is resorbed. They are likely important not only in the control of normal bone remodeling, but also in a number of disease states associated with disordered remodeling. In this review, current concepts of the effects of these factors on cells in the osteoclast lineage will be discussed.

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