Role of cytochrome P450 IA2 in acetanilide 4-hydroxylation as determined with cDNA expression and monoclonal antibodies

Stable expression of rat cytochrome P450

Stable expression of rat cytochrome P450IA2 cDNA and hydroxylation of 17β-estradiol and 2-aminofluorene in V79 Chinese hamster cells

✍ Catherine Wölfel; Karl-Ludwig Platt; Satish Dogra; Hansruedi Glatt; Felix Wächte 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 English ⚖ 820 KB

In continuation of our work toward the establishment of a working cell bank for metabolic and toxicological studies, V79 Chinese hamster cells were genetically engineered for stable expression of rat cytochrome P450IA2. Full-length cDNA encoding rat P450IA2 was obtained by searching a cDNA library m