Role of corticotropin-releasing factor in stress-related visceral hyperalgesia
β Scribed by Hiroshi Kaneko
- Publisher
- Springer Japan
- Year
- 2006
- Tongue
- English
- Weight
- 115 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0944-1174
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The effects of corticotropin-releasing factor (CRF) and previously published effect of stress on the locomotor activity of mice in different regions of an open field were compared. Intracerebroventricular (ICV) administration of 0.2 microgram CRF, like stress, significantly increased center region a
## Abstract Corticotropinβreleasing factor agonists exert inhibitory effects in stomach functions possibly through peripheral routes. We have previously reported the expression of Urocortin (Ucn) I, an endogenous ligand of both CRF receptor types CRF~1~ and CRF~2~, in the human stomach. We examined