Transmission of antibody-induced arthrit
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Samuel Solomon; Cornelia Kolb; Subhasis Mohanty; Elvira Jeisy-Walder; Rosemarie
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Article
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2002
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John Wiley and Sons
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English
โ 223 KB
๐ 1 views
The K/BxN murine model of rheumatoid arthritis (RA) is dependent on the specificity of the KRN ยง g -TCR, to recognize glucose-6-phosphate-isomerase (GPI) on the NOD MHC class II A g7 allele and production of GPI-specific autoantibodies. Transfer of K/BxN serum into MHCunrelated and lymphocyte-defici