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Role of complement in osteoclast differentiation

✍ Scribed by Zhidan Tu; Hong Bu; James E. Dennis; Feng Lin

Book ID: 113805160
Publisher: Elsevier Science
Year: 2010
Tongue: English
Weight: 73 KB
Volume: 47
Category: Article
ISSN: 0161-5890
DOI: 10.1016/j.molimm.2010.05.167

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## Abstract Osteoclasts are specialized macrophage derivatives that secrete acid and proteinases to mobilize bone for mineral homeostasis, growth, and replacement or repair. Osteoclast differentiation generally requires the monocyte growth factor m‐CSF and the TNF‐family cytokine RANKL, although di