Role of colony stimulating factor-1 (CSF-1) and other lympho-hematopoietic growth factors in mouse pre-implantation development

✍ Scribed by Serge Pampfer; Robert J. Arceci; Jeffrey W. Pollard

• Publisher: John Wiley and Sons
• Year: 1991
• Tongue: English
• Weight: 771 KB
• Volume: 13
• Category: Article
• ISSN: 0265-9247
• DOI: 10.1002/bies.950131007

✦ Synopsis

Mouse pre-implantation development appears to be under the control of paracrinc and autocrine growth factors. The epithclium of the oviduct and the uterus together, with the population of macrophages and lymphocytes present in the reproductive tract from the onset of pregnancy, are thought to he the major sources of paracrine growth factors targeted to the developing embryos. Some of the growth factors are synthesized by both uterine epithelial cells and activated lymphohematopoietic cells, suggesting a partial overlap of thc regulatory signals used by the reproductive and lymphohematopoietic systems. Such growth factors may be the long sought-after mediators of the synchrony between the pre-implantation embryo and the sex-steroid hormone-induced changes in the uterus.