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Role of Cbfa1/Runx2 in the fluid shear stress induction of COX-2 in osteoblasts

✍ Scribed by Meenal Mehrotra; Masatomo Saegusa; Olga Voznesensky; Carol Pilbeam

Book ID: 116292278
Publisher: Elsevier Science
Year: 2006
Tongue: English
Weight: 271 KB
Volume: 341
Category: Article
ISSN: 0006-291X
DOI: 10.1016/j.bbrc.2006.01.084

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Core binding factor alpha 1 (Cbfa1) is an osteoblast-specific transcription factor essential to develop a mature osteoblast phenotype. However, its exact role in the signaling of various osteotropic-differentiating agents is still unclear. In this study, we assessed the effects of 1,25-(OH)(2)-D3 (D