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Role of caspases and mitochondria in Siglec-8-mediated eosinophil apoptosis

✍ Scribed by Nutku, E.; Hudson, S.; Bochner, B.S.

Book ID
119491987
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
140 KB
Volume
111
Category
Article
ISSN
1097-6825

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## Abstract The mitochondria‐mediated apoptotic pathway is regulated by members of the Bcl‐2 family. Epidermal growth factor (EGF) induces Bad phosphorylation at Ser~112~ via mitogen‐activated protein kinase (MAPK), impairing its binding to Bcl‐2 and Bcl‐xL and interfering with their anti‐apoptotic