Role of calcium in the release of EC 3.4.24.15 and EC 3.4.24.16 from endothelial cells
β Scribed by M. Ursula Norman; A. Ian Smith; Rebecca A. Lew
- Publisher
- Springer Netherlands
- Year
- 1999
- Tongue
- English
- Weight
- 327 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1573-3149
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## Abstract Endopeptidase 24.15 (EP24.15) and 24.16 (EP24.16) are closely related metalloendopeptidases implicated in the metabolism of several neuropeptides and widely expressed in mammalian brain. To gain insight into the functional role of these two enzymes in the central nervous system, we exam
## Abstract Neuropeptide processing metalloenzymes, such as angiotensin converting enzyme, neprilysin, endothelin converting enzyme, neurolysin, and EC3.4.24.15 (EP24.15), are central to the formation and degradation of bioactive peptides. We present EP24.15 as a paradigm for novel functions ascrib
## Abstract Endopeptidase EC 3.4.24.15 (EP 24.15; thimet oligopeptidase) is a soluble metalloendopeptidase implicated in the metabolism of a number of neuropeptides, including neurotensin, gonadotropinβreleasing hormone, and opioid peptides. We have shown previously that thiol reducing agents, such