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Role of cadherin-11 in synovial joint formation and rheumatoid arthritis pathology

โœ Scribed by Dou, Ce; Yan, Yanfei; Dong, Shiwu

Book ID
121377796
Publisher
Springer
Year
2012
Tongue
English
Weight
253 KB
Volume
23
Category
Article
ISSN
1439-7595

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Modulation of matrix metalloproteinase production by rheumatoid arthritis synovial fibroblasts after cadherin 11 engagement
โœ Erika H. Noss; Sook Kyung Chang; Gerald F. M. Watts; Michael B. Brenner ๐Ÿ“‚ Article ๐Ÿ“… 2011 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 239 KB

Objective. Cadherin 11 is a homophilic cell-to-cell adhesion molecule expressed on joint synovial fibroblasts. Absence of cadherin 11 in a mouse rheumatoid arthritis (RA) model led to striking reductions in cartilage erosion. Matrix metalloproteinases (MMPs) are enzymes expressed by synovial fibrobl