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Role of Ca2+-activated Cl− channels in the mechanism of apoptosis induced by cyclosporin A in a human hepatoma cell line

✍ Scribed by Jung-Ae Kim; Young Shin Kang; Yong Soo Lee

Book ID: 116286902
Publisher: Elsevier Science
Year: 2003
Tongue: English
Weight: 203 KB
Volume: 309
Category: Article
ISSN: 0006-291X
DOI: 10.1016/j.bbrc.2003.07.004

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## Abstract ## Background The caspase‐3 gene is expressed at significantly lower levels in human hepatocellular carcinomas than in normal hepatocytes. Gene transfer technologies offer the possibility to restore caspase‐3 gene expression. We explored the interest for cancer gene therapy of a consti