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Role of BRCA1 in cellular resistance to paclitaxel and ionizing radiation in an ovarian cancer cell line carrying a defective BRCA1

โœ Scribed by Zhou, Chenyi; Smith, Janice L; Liu, Jinsong


Book ID
110067434
Publisher
Nature Publishing Group
Year
2003
Tongue
English
Weight
266 KB
Volume
22
Category
Article
ISSN
0950-9232

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Germ-line mutations of the BRCA1 and BRCA2 genes predispose women to develop cancers of the breast and ovary, but the biologic functions of these genes remains unclear. We have investigated the responses of the BRCA1 and BRCA2 gene products to cytotoxic agents in 3 human ovarian cancer cell lines: S