Portal hypertension (PHT) is characterized by increased portal pressure caused in part by a reduction in mesenteric vascular resistance. The aim of this study was to evaluate the role of endothelin (ET) and specific ET receptors in maintaining the vasculopathy of PHT. PHT was created in Sprague-Dawl
Role of bile acids in splanchnic hemodynamic response to chronic portal hypertension
โ Scribed by Stephen H. Thomas; Takashi Joh; Joseph N. Benoit
- Book ID
- 112512758
- Publisher
- Springer US
- Year
- 1991
- Tongue
- English
- Weight
- 568 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0163-2116
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Ketanserin, a serotonin antagonist, is effective in lowering portal pressure in a rat model of portal hypertension. As ketanserin has al-adrenoceptor-blocking properties in addition to its serotonin-blocking effects, we sought to define further the mechanism of ketanserin's portal pressure-lowering