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Role of astrocytes in glutamate homeostasis: Implications for excitotoxicity

✍ Scribed by Arne Schousboe; Helle S. Waagepetersen

Publisher
Springer-Verlag
Year
2005
Tongue
English
Weight
865 KB
Volume
8
Category
Article
ISSN
1029-8428

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✦ Synopsis

Glutamate homeostasis in the brain is maintained by its well balanced release, uptake and metabolism. It appears that astrocytes play a prominent role in this context since they possess a very powerful battery of glutamate transporters. Thus, malfunction of astrocytic glutamate transporters will lead to an excessively high extracellular glutamate concentration which may result in neurodegeneration caused by the excitotoxic action of glutamate.

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