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Role of angiotensin II AT1and AT2subtype receptors in the regulation of atrial natriuretic peptide expression in salt-restricted rats

✍ Scribed by Bruna Gigante; Ornella Piras; Carmine Savoia; Paola De Paolis; Speranza Rubattu; Gaia Panina; Massimo Volpe

Publisher: Springer
Year: 2000
Tongue: English
Weight: 84 KB
Volume: 95
Category: Article
ISSN: 0300-8428
DOI: 10.1007/s003950050009

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## Abstract Bradykinin (BK) and angiotensin II (AngII) often have opposite roles in cardiovascular diseases. Our aim here was to construct hybrid receptors which bind AngII but signal as BK. Various sequences of the intracellular face of the AngII type I receptor, AT1R, were replaced with correspon