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Role of Active Oxygen Species and Lipid Peroxidation in Mepirizole-Induced Duodenal Ulcers in Rats

✍ Scribed by Shoji Iinuma; Toshikazu Yoshikawa; Norimasa Yoshida; Yuji Naito; Motoharu Kondo

Book ID
110379099
Publisher
Springer US
Year
1998
Tongue
English
Weight
324 KB
Volume
43
Category
Article
ISSN
0163-2116

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## Abstract Treatment of rats with 100 mg kg^βˆ’1^ __t__‐butyl hydroperoxide led to an enhanced ethane exhalation as a marker of __in vivo__ lipid peroxidation, as well as a moderate hepatoxicity as evidenced by a rise in plasma activities of liver‐specific enzymes (glutamate‐pyruvate transaminase an