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Role of activated nuclear factor-κB in the pathogenesis and therapy of squamous cell carcinoma of the head and neck

✍ Scribed by Clint T. Allen; Justin L. Ricker; Zhong Chen; Carter Van Waes

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
689 KB
Volume
29
Category
Article
ISSN
1043-3074

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✦ Synopsis

Abstract

Background:

Nuclear factor‐κB (NF‐κB), a transcription factor known to modulate expression of factors involved in inflammation, immunity, proliferation, and apoptosis, is constitutively activated and plays a role in pathogenesis and therapeutic resistance in head and neck squamous cell carcinoma (HNSCC). Understanding the molecular alterations leading to aberrant NF‐κB activation in HNSCC may direct investigators to novel therapeutic targets.

Methods:

Results of laboratory and clinical studies are reviewed.

Results:

The structure, function, and activation of NF‐κB, products of NF‐κB target genes and their role in HNSCC oncogenesis, and current NF‐κB modulating interventions are described.

Conclusions:

Aberrant NF‐κB activation contributes to the expression of oncogenes and the malignant phenotype observed in HNSCC. NF‐κB, along with providing a link between cancer and inflammation, may serve as an appropriate therapeutic target to inhibit tumor growth and sensitize cancer cells to established cytotoxic anticancer therapies. © 2007 Wiley Periodicals, Inc. Head Neck, 2007

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