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Role of a ubiquitin-conjugating enzyme in degradation of S- and M-phase cyclins

✍ Scribed by Seufert, Wolfgang; Futcher, Bruce; Jentsch, Stefan


Book ID
109790788
Publisher
Nature Publishing Group
Year
1995
Tongue
English
Weight
504 KB
Volume
373
Category
Article
ISSN
0028-0836

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The ubiquitin/proteasome pathway is a highly conserved mechanism of proteolysis in all eukaryotes. Ubiquitin (Ub) is conjugated to proteolytic substrates through the sequential action of ubiquitin-activating (E1/Uba) and ubiquitin-conjugating (E2/Ubc) enzymes. The mechanism of substrate recognition